Pompeo is alluding to two different things there.
First up is a rant against Iran, which he considers Obama was soft on. This is not a military threat, its all about the sanctions and the nuclear agreement. Trump obviously takes a different line to Obama (and the EU) in these matters. But Trumps line is popular in the sunni dominated countries to the south of Iran. The very ones that were also hoping to overthrow Assad in Syria.
Second up is a rant against IS. This one is a military matter. Trump said in his election campaign that the US needed to get boots on the ground in Syria and destroy IS, and then get out afterwards. Trump is the only leader I know who actually tries to deliver on his election pledges. We can say he has delivered on this one now.
Obama funded various rebel groups, but never had a decisive strategy in Syria.
Again, Trumps strategy is favoured in the region because nobody really liked IS. Even the sunni countries like Turkey and Saudi Arabia feared them because they threatened the established order in the region. They were anti-monarchy and anti-secular republic. They would have overturned the governments of Turkey and S.A. if they could have. But at the same time they were being used by these governments against Assad.
Now everyone in the region realises that the game is over, and Assad has won. They want to forgive and forget, and pretend that they didn't try to kill him. But Assad will remember his friends; the Iranians and the Russians.